Vaginal Ovules & Suppositories Manufacturing. Let’s get the basics right.
Vaginal Ovules & Suppositories Manufacturing. Let’s get the basics right. Q1 What are suppositories and what benefits do they offer? Suppositories are medicated solid formulations that are inserted into the body through the rectum, vagina, or urethra. They are usually small, round, or cone-shaped dosage forms designed to deliver drugs through rectal and vaginal routes, especially […]
cGMP Issues are increasing in Pharma Manufacturing. Let’s keep focusing on Best Practice.
cGMP Issues are increasing in Pharma. Let’s keep focused on Quality & People. Big Pharma and small companies alike are failing when it comes to cGMP violations. The increasing number and complexity of global regulations, outsourcing, price pressures, and compressed time to market all contribute to these failures. Consequently, the number of compliance issues is […]
Overcome The Challenges Of Small Batch Production While Maximizing Yield.
Overcome The Challenges Of Small Batch Production While Maximizing Yield. A focus on niche drugs for targeted patient populations has led to an increase in small batch production across the pharmaceutical industry. These products include advanced therapy medicinal products (ATMPs) and high-value biologics that require very complex production processes or the use of expensive active […]
Key Considerations in Capsule Filling
Key Considerations in Capsule Filling Capsule filling is a complex process, and the product to be encapsulated must be well developed to ensure mass uniformity. Iñaki Bueno, formulation and manufacturing manager at Idifarma, and Rob Harris, chief technical officer at Juniper Pharma Services, share insights on the challenges of capsule filling. PharmTech: What type of […]
Sticky Formulations? Let’s look at how to overcome capsule-filling issues.
Sticky Formulations? Let’s look at how to overcome capsule-filling issues. This guide provides a best-practices approach to troubleshooting capsule-filling problems when handling a sticky product formulation. A sticky formulation is one of the most common causes of issues during capsule filling. A capsule filler requires tight tolerances between the machine’s tooling components, including the dosing […]
Process Validation: Smarter Manufacturing data management.
Process Validation: Smarter Manufacturing data management. Data is prevalent through all functions of the Life Science industry. Its value impacts many disciplines throughout an organization, and while the use of data by discipline varies, it always involves: Gathering and aggregating multiple types of data from multiple sources Making that data available across an organization […]
New drug-delivery capsule may replace injections
Can capsule deliver insulin? New technology say yes! Capsule that releases insulin in the stomach could replace injections for patients with type 1 diabetes. An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing the injections that people with type 1 diabetes have to give […]
Virtual Factory Acceptance Testing: Dos And Don’ts.
Virtual Factory Acceptance Testing: Dos And Don’ts. Factory acceptance testing (FAT) is a critical process that relies on strong relationships between a life science manufacturer and its equipment vendor, as well as suitable technology and infrastructure. A smooth and successful FAT is often vital to the client’s production timeline. The FAT is performed at the […]
How do you choose the right capsule shell material?
How do you choose the right capsule shell material? Patented in 1834, gelatin a natural water-soluble polypeptide which is obtained from connective tissues, skins and bones of animals has long been used in the pharmaceutical industry to encapsulate solids, semi solids and even liquid drugs owing to its excellent film forming and gelling capacity. It […]
An introduction to Gene & Cell Therapy
We want to talk about Cell & Genes therapy due to their role in treating diseases with a more profound impact on people and their lives. It is estimated that millions of people globally suffer from more than 10.000 rare diseases caused by mutations of single genes. For these patients, cell and gene therapies offer […]